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From Cell Biology to Clinical Cancer Pathology

Entosis: From Cell Biology to Clinical Cancer Pathology

 

Entosis is a phenomenon, in which one cell enters a second one. New clinico-histopathological studies of entosis prompted us to summarize its significance in cancer. It appears that entosis might be a novel, independent prognostic predictor factor in cancer histopathology.

We briefly discuss the biological basis of entosis, followed by a summary of published clinico-histopathological studies on entosis significance in cancer prognosis. The correlation of entosis with cancer prognosis in head and neck squamous cell carcinoma, anal carcinoma, lung adenocarcinoma, pancreatic ductal carcinoma and breast ductal carcinoma, is shown.

Numerous entotic figures are associated with a more malignant cancer phenotype and poor prognosis in many cancers. We also showed that some anticancer drugs could induce entosis in cell culture, even as an escape mechanism. Thus, entosis is likely beneficial for survival of malignant cells, i.e., an entotic cell can hide from unfavourable factors in another cell and subsequently leave the host cell remaining intact, leading to failure in therapy or cancer recurrence.

Finally, we highlight the potential relationship of cell adhesion with entosis in vitro, based on the model of the BxPc3 cells cultured in full adhesive conditions, comparing them to a commonly used MCF7 semiadhesive model of entosis.

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Cdc42 Activation Assay

STA-402 20 assays
EUR 757
Description: Our Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of Cdc42 protein. The precipitated small GTPase is then detected by Western blot using a Cdc42-specific antibody included in the kit.

RhoA Activation Assay

STA-403-A 20 assays
EUR 757
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoB Activation Assay

STA-403-B 20 assays
EUR 757
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoC Activation Assay

STA-403-C 20 assays
EUR 757
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

Arf1 Activation Assay

STA-407-1 20 assays
EUR 757
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Arf6 Activation Assay

STA-407-6 20 assays
EUR 757
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Ral Activation Assay

STA-408 20 assays
EUR 757
Description: Our Ral Activation Assay uses visible agarose beads to selectively precipitate the active form of Ral protein. The precipitated small GTPase is then detected by Western blot using a Ral-specific antibody included in the kit.

Ran Activation Assay

STA-409 20 assays
EUR 757
Description: Our Ran Activation Assay uses visible agarose beads to selectively precipitate the active form of Ran protein. The precipitated small GTPase is then detected by Western blot using a Ran-specific antibody included in the kit.

Pan-RAS-IN-1

HY-101295 25mg
EUR 1703

Rap1 Activation Assay Kit

STA-406-1 20 assays
EUR 757
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Rap2 Activation Assay Kit

STA-406-2 20 assays
EUR 757
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Rac1 Activation Assay Kit, Trial Size

STA-401-1-T 5 assays
EUR 403
Description: Our Rac Activation Assays use visible agarose beads to selectively precipitate the active form of Rac1 or Rac2. The precipitated small GTPase is then detected by Western blot using a Rac1- or Rac2-specific antibody included in the kit.

Rac2 Activation Assay Kit, Trial Size

STA-401-2-T 5 assays
EUR 403
Description: Our Rac Activation Assays use visible agarose beads to selectively precipitate the active form of Rac1 or Rac2. The precipitated small GTPase is then detected by Western blot using a Rac1- or Rac2-specific antibody included in the kit.

Cdc42 Activation Assay Kit, Trial Size

STA-402-T 5 assays
EUR 403
Description: Our Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of Cdc42 protein. The precipitated small GTPase is then detected by Western blot using a Cdc42-specific antibody included in the kit.

RhoA Activation Assay Kit, Trial Size

STA-403-A-T 5 assays
EUR 403
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoB Activation Assay Kit, Trial Size

STA-403-B-T 5 assays
EUR 403
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoC Activation Assay Kit, Trial Size

STA-403-C-T 5 assays
EUR 403
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

Rac1/Cdc42 Activation Assay Combo Kit

STA-404 2 x 20 assays
EUR 1088
Description: Our Rac1/Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of the small GTPase. The precipitated small GTPase is then detected by Western blot using a specific antibody included in the kit.

Rap1 Activation Assay Kit, Trial Size

STA-406-1-T 5 assays
EUR 403
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Rap2 Activation Assay Kit, Trial Size

STA-406-2-T 5 assays
EUR 403
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Arf1 Activation Assay Kit, Trial Size

STA-407-1-T 5 assays
EUR 403
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Arf6 Activation Assay Kit, Trial Size

STA-407-6-T 5 assays
EUR 403
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Ral Activation Assay Kit, Trial Size

STA-408-T 5 assays
EUR 403
Description: Our Ral Activation Assay uses visible agarose beads to selectively precipitate the active form of Ral protein. The precipitated small GTPase is then detected by Western blot using a Ral-specific antibody included in the kit.

Ran Activation Assay Kit, Trial Size

STA-409-T 5 assays
EUR 403
Description: Our Ran Activation Assay uses visible agarose beads to selectively precipitate the active form of Ran protein. The precipitated small GTPase is then detected by Western blot using a Ran-specific antibody included in the kit.

RhoA/Rac1/CDC42 Activation Assay Combo Kit

STA-405 3 x 10 assays
EUR 1088
Description: Our RhoA/Rac1/Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of the small GTPase. The precipitated small GTPase is then detected by Western blot using a specific antibody included in the kit.

96-Well Ras Activation ELISA Kit (Colorimetric)

STA-440 96 assays
EUR 902
Description: Our 96-Well Ras Activation ELISA Kit uses the Raf1 RBD (Rho binding domain) bound to a 96-well plate to selectively pull down the active form of Ras from purified or endogenous samples. The captured GTP-Ras is then detected by a pan-Ras antibody and HRP-conjugated secondary antibody.

96-Well Ras Activation ELISA Kit (Chemiluminescent)

STA-441 96 assays
EUR 902
Description: Our 96-Well Ras Activation ELISA Kit uses the Raf1 RBD (Rho binding domain) bound to a 96-well plate to selectively pull down the active form of Ras from purified or endogenous samples. The captured GTP-Ras is then detected by a pan-Ras antibody and HRP-conjugated secondary antibody.

Pan-PAX (Pan-PAX) Antibody

abx236136-100ug 100 ug
EUR 481

Cytokeratin, pan (Epithelial Marker); Clone PAN-CK (Concentrate)

RA0430-C.5 0.5 ml
EUR 300

Rabbit Anti-Human IgG, Antisera (Bulk)

10119-RAS-BLK 1-10L, bulk Ask for price

Rabbit Anti-Llama IgG (H+L chain), Antisera (Bulk)

30818-RAS-BLK 1-10L, bulk Ask for price

Rabbit Anti-Goat IgG, Antisera (Bulk)

60319-RAS-BLK 1-10L, bulk Ask for price

Rabbit Anti-Mouse IgG, Antisera (Bulk)

44319-RAS-BLK 1-10L, bulk Ask for price

Pan myristoylation Antibody

1-CSB-PA885152
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Pan myristoylation. Recognizes Pan myristoylation from ALL. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-10000, ELISA:1:10000

Pan myristoylation Antibody

1-CSB-PA465729
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Pan myristoylation. Recognizes Pan myristoylation from ALL. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-10000, ELISA:1:10000

pan Akt/KinaseB

MO15107 100 ug
EUR 435

NMDA NR1 Pan

MO25041 15 ug
EUR 592

pan-Cytokeratin antibody

23032-100ul 100ul
EUR 390

pan-AKT Antibody

36716-100ul 100ul
EUR 252

pan CDH Antibody

37301-100ul 100ul
EUR 252

Actin-pan Antibody

33321-100ul 100ul
EUR 252

Actin-pan Antibody

33321-50ul 50ul
EUR 187

Synuclein-pan Antibody

33495-100ul 100ul
EUR 252

Synuclein-pan Antibody

33495-50ul 50ul
EUR 187

Pan-AKT Antibody

20-abx125375
  • EUR 592.00
  • EUR 857.00
  • EUR 411.00
  • 100 ul
  • 200 ul
  • 50 ul

Pan myristoylation Antibody

20-abx322788
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Pan myristoylation Antibody

20-abx322789
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

pan-AKT Antibody

20-abx002260
  • EUR 411.00
  • EUR 592.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul

pan Cadherin Antibody

20-abx149140
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug

NBPF-pan Antibody

20-abx008107
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

SSX-pan Antibody

20-abx008681
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Actin-pan Antibody

20-abx013019
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Synuclein-pan Antibody

20-abx013202
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Pan SUMO Antibody

abx027085-400ul 400 ul
EUR 523

Pan SUMO Antibody

abx027085-80l 80 µl
EUR 286

Pan SUMO Antibody

abx027140-400ul 400 ul
EUR 523

Pan SUMO Antibody

abx027140-80l 80 µl
EUR 286

Pan pLDH Antibody

abx023860-1mg 1 mg
EUR 342

Pan pLDH Antibody

abx023861-1mg 1 mg
EUR 342

Pan Ubiquitin Antibody

abx415347-50ug 50 ug
EUR 565

pan ADH Antibody

abx433090-200ul 200 ul
EUR 384

SHANK (pan) Antibody

abx440129-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx440140-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx440246-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx440410-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx440421-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx440527-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx440691-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx440702-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx440808-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx440972-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx440983-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx441089-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx441253-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx441264-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx441370-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx441534-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx441545-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx441651-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx441815-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx441826-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx441932-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx442096-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx442107-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx442213-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx442377-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx442388-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx442494-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx442658-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx442669-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx442775-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx442938-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx442949-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx443055-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx443218-100ug 100 ug
EUR 565

SAPAP (pan) Antibody

abx443229-100ug 100 ug
EUR 565

Ankyrin (pan) Antibody

abx443335-100ug 100 ug
EUR 565

SHANK (pan) Antibody

abx443499-100ug 100 ug
EUR 565

SAPAP (pan) Antibody

abx443510-100ug 100 ug
EUR 565

Ankyrin (pan) Antibody

abx443616-100ug 100 ug
EUR 565

SHANK (pan) Antibody

abx443780-100ug 100 ug
EUR 592

SAPAP (pan) Antibody

abx443791-100ug 100 ug
EUR 592

Ankyrin (pan) Antibody

abx443897-100ug 100 ug
EUR 592

SHANK (pan) Antibody

abx444061-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx444072-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx444178-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx444342-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx444353-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx444459-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx444623-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx444634-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx444740-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx444980-100ug 100 ug
EUR 523

SAPAP (pan) Antibody

abx444991-100ug 100 ug
EUR 523

GRK (pan) Antibody

abx445060-100ug 100 ug
EUR 523

QKI (pan) Antibody

abx445076-100ug 100 ug
EUR 523

Ankyrin (pan) Antibody

abx445097-100ug 100 ug
EUR 523

pan Cadherin Antibody

abx217630-100ug 100 ug
EUR 439

pan-AKT antibody

38602-100ul 100ul
EUR 252

pan Cadherin Antibody

45029-100ul 100ul
EUR 252

pan Cadherin Antibody

45029-50ul 50ul
EUR 187

pan Cadherin Antibody

45052-100ul 100ul
EUR 252

pan Cadherin Antibody

45052-50ul 50ul
EUR 187

Pan-Cadherin Antibody

48907-100ul 100ul
EUR 333

Pan-Cadherin Antibody

48907-50ul 50ul
EUR 239

Melanoma; Pan (Concentrate)

A00134-C 1 ml
EUR 676

Melanoma; Pan (Concentrate)

A00134-C.1 0.1 ml
EUR 138

PKC-pan Antibody

AF6197 200ul
EUR 304
Description: PKC-pan Antibody detects endogenous levels of total PKC-pan.

pan- AKT Antibody

ABD7208 100 ug
EUR 438

pan Cadherin Antibody

ABD7514 100 ug
EUR 438

Actin- pan Antibody

ABF0115 100 ug
EUR 438

Actin- pan Antibody

ABF5288 100 ug
EUR 438

pan-AKT Antibody

DF7208 200ul
EUR 304
Description: pan-AKT Antibody detects endogenous levels of total pan-AKT.

pan Cadherin Antibody

DF7514 200ul
EUR 304
Description: pan Cadherin Antibody detects endogenous levels of total pan Cadherin.

Pan Methylated Lysine

DF7728 200ul
EUR 304
Description: Pan Methylated Lysine Rabbit pAbdetects endogenous levels of total Pan Methylated Lysine Rabbit pAb.

pan Cadherin Antibody

DF2942 200ul
EUR 304
Description: pan Cadherin Antibody detects endogenous levels of total pan Cadherin.

pan Cadherin Antibody

ABD2942 100 ug
EUR 438

anti-pan-Synuclein

LF-PA0194 100 ul
EUR 334
Description: Rabbit polyclonal to pan-Synuclein

pan Endothelium antibody

10R-6386 100 ug
EUR 284
Description: Mouse monoclonal pan Endothelium antibody

pan Cadherin antibody

10R-7890 100 ug
EUR 322
Description: Mouse monoclonal pan Cadherin antibody

Actin-pan antibody

10R-A106a 100 ug
EUR 553
Description: Mouse monoclonal Actin-pan antibody

pan Cytokeratin antibody

10R-2060 100 ul
EUR 403
Description: Mouse monoclonal pan Cytokeratin antibody

Cytokeratin Pan antibody

10R-2096 100 ul
EUR 403
Description: Mouse monoclonal Cytokeratin Pan antibody

pan Keratin antibody

10R-2442 50 ug
EUR 405
Description: Mouse monoclonal pan Keratin antibody

PKC- pan Antibody

ABF6197 100 ug
EUR 438

Actin-pan Antibody

AF0115 200ul
EUR 304
Description: Actin-pan antibody detects endogenous levels of total Actin-pan.

LDH Pan antibody

10-1335 1 mg
EUR 259
Description: Mouse monoclonal LDH Pan antibody

LDH Pan antibody

10-1336 1 mg
EUR 259
Description: Mouse monoclonal LDH Pan antibody

Keratin pan antibody

20R-2530 250 uL
EUR 510
Description: Rabbit polyclonal Keratin pan antibody

Synuclein pan antibody

70R-30766 100 ug
EUR 327
Description: Rabbit polyclonal Synuclein pan antibody

Actin pan antibody

70R-31095 100 ug
EUR 327
Description: Rabbit polyclonal Actin pan antibody

PKC pan antibody

70R-33408 100 ug
EUR 327
Description: Rabbit polyclonal PKC pan antibody

SSX pan antibody

70R-50426 100 ul
EUR 244
Description: Purified Polyclonal SSX pan antibody

NBPF pan antibody

70R-51031 100 ul
EUR 244
Description: Purified Polyclonal NBPF pan antibody

FOXO1 pan antibody

70R-37057 100 ug
EUR 327
Description: Rabbit Polyclonal FOXO1 pan antibody

Pan Keratin antibody

PAab09935 100 ug
EUR 386

H3 Pan Antibody

6806-50
EUR 316

RAS Antibody

31153-100ul 100ul
EUR 252

RAS Antibody

31153-50ul 50ul
EUR 187

Ras Antibody

48578-100ul 100ul
EUR 333

Ras Antibody

48578-50ul 50ul
EUR 239

Ras Antibody

48602-100ul 100ul
EUR 333

Ras Antibody

48602-50ul 50ul
EUR 239

Ras Antibody

49408-100ul 100ul
EUR 333

Ras Antibody

49408-50ul 50ul
EUR 239

RAS antibody

10R-1779 100 ul
EUR 349
Description: Mouse monoclonal RAS antibody

XTT CELL VIABILITY ASSAY KIT (1000 ASSAY)

30007 1KIT
EUR 236
Description: Minimum order quantity: 1 unit of 1KIT

Ras-Related Protein M-Ras (MRAS) Antibody

20-abx113895
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Ras-Related Protein R-Ras (RRAS) Antibody

20-abx123552
  • EUR 495.00
  • EUR 356.00
  • 100 ul
  • 50 ul

Ras-Related Protein R-Ras (RRAS) Antibody

abx026316-400ul 400 ul
EUR 523

Ras-Related Protein R-Ras (RRAS) Antibody

abx026316-80l 80 µl
EUR 286

Ras-Related Protein R-Ras (RRAS) Protein

20-abx262883
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg

Ras-Related Protein R-Ras (RRAS) Antibody

abx237489-100ug 100 ug
EUR 509

Ras-related protein R-Ras (RRAS) Antibody

20-abx241995
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Ras-related protein R-Ras (RRAS) Antibody

20-abx214133
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Monoclonal Cytokeratin, pan (Epithelial Marker) Antibody, Clone: PAN-CK (Cocktail)

APR14636G 7 ml
EUR 484
Description: A Monoclonal antibody against Human Cytokeratin, pan (Epithelial Marker). The antibodies are raised in Mouse and are from clone PAN-CK (Cocktail). This antibody is applicable in WB, IHC and IF, FC

Endothelial Tube Formation Assay (In Vitro Angiogenesis Assay)

CBA-200 50 assays
EUR 560
Description: For angiogenesis to occur, endothelial cells must escape their stable location and break through the basement membrane. Cells migrate toward an angiogenic stimulus that may be released from nearby tumor cells. These cells proliferate to form new blood vessels. Our Endothelial Tube Formation Assay (In Vitro Angiogenesis) provides an easy, robust system to assess angiogenesis in vitro. The ECM gel matrix very closely resembles an in vivo environment.

Pan Methyl Lysine Antibody

1-CSB-PA000391
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Pan Methyl Lysine. Recognizes Pan Methyl Lysine from . This antibody is Unconjugated. Tested in the following application: WB;WB:1:1000-2000

Pan myristoylation Polyclonal Antibody

ES8552-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Pan myristoylation from ALL. This antibody is tested and validated for WB, ELISA, WB, ELISA

Pan myristoylation Polyclonal Antibody

ES8552-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Pan myristoylation from ALL. This antibody is tested and validated for WB, ELISA, WB, ELISA

Pan myristoylation Polyclonal Antibody

ES8553-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Pan myristoylation from ALL. This antibody is tested and validated for WB, ELISA, WB, ELISA

Pan myristoylation Polyclonal Antibody

ES8553-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Pan myristoylation from ALL. This antibody is tested and validated for WB, ELISA, WB, ELISA

Keratin-pan Polyclonal Antibody

ES8630-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Keratin-pan from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Keratin-pan Polyclonal Antibody

ES8630-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Keratin-pan from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Keratin-pan Polyclonal Antibody

ES4059-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Keratin-pan from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MYH-pan Polyclonal Antibody

ES4157-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MYH-pan from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MYH-pan Polyclonal Antibody

ES4157-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MYH-pan from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Keratin-pan Polyclonal Antibody

ES4059-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Keratin-pan from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Anti-Pan PKC antibody

STJ119907 100 µl
EUR 277

Anti-Periostin pan antibody

STJ120192 100 µl
EUR 526

 

Recent advances in myeloid-derived suppressor cell biology

In recent years, studying the role of myeloid-derived suppressor cells (MDSCs) in many pathological inflammatory conditions has become a very active research area. Although the role of MDSCs in cancer is relatively well established, their role in non-cancerous pathological conditions remains in its infancy resulting in much confusion.

Our objectives in this review are to address some recent advances in MDSC research in order to minimize such confusion and to provide an insight into their function in the context of other diseases. The following topics will be specifically focused upon: (1) definition and characterization of MDSCs; (2) whether all MDSC populations consist of immature cells;

(3) technical issues in MDSC isolation, estimation and characterization; (4) the origin of MDSCs and their anatomical distribution in health and disease; (5) mediators of MDSC expansion and accumulation; (6) factors that determine the expansion of one MDSC population over the other; (7) the Yin and Yang roles of MDSCs. Moreover, the functions of MDSCs will be addressed throughout the text.

 

MRGPRX2 signals its importance in cutaneous mast cell biology: Does MRGPRX2 connect mast cells and atopic dermatitis?

The discovery of MRGPRX2 marks an important change in MC biology, explaining non-IgE-mediated clinical phenomena relying on MCs. As receptor for multiple drugs, MRGPRX2 is crucial to drug-induced hypersensitivity.

However, not only drugs, but also endogenous mediators like neuropeptides and host defense peptides activate MRGPRX2, suggesting its broad impact in cutaneous pathophysiology. Here, we give a brief overview of MRGPRX2 and its regulation by microenvironmental stimuli, which support MCs and can be altered in skin disorders, and briefly touch on the functional programs elicited by MRGPRX2 ligation. Studies in Mrgprb2-deficient mice (the murine ortholog) help illuminate MRGPRX2’s function in health and disease.

Recent advances in this model support the long-suspected operational unit between MCs and nerves, with MRGPRX2 being a vital component. Based on the limited evidence for a major contribution of FcεRI/IgE-activated MCs to atopic dermatitis (AD), we develop the hypothesis that MRGPRX2 constitutes the missing link connecting MCs and AD, at least in selected endotypes. Support comes from the multifold changes in the MC-neuronal system of AD skin (e.g. greater density of MCs and closer connections between MCs and nerves, increased PAR-2/Substance P).

We theorize that these deregulations suffice to initiate AD, but external triggers, many of which activating MRGPRX2 themselves (e.g. Staphylococcus aureus) further feed into the loop. Itch, the most burdensome hallmark of AD, is mostly non-histaminergic but tryptase-dependent, and tryptase is preferentially released upon MRGPRX2 activation. Because MRGPRX2 is a very active research field, some of the existing gaps are likely to be closed soon.

The vimentin cytoskeleton: When polymer physics meets cell biology

The proper functions of tissues depend on the ability of cells to withstand stress and maintain shape. Central to this process is the cytoskeleton, comprised of three polymeric networks: F-actin, microtubules, and intermediate filaments.
Intermediate filament proteins are among the most abundant cytoskeletal proteins in cells; yet they remain some of the least understood. Their structure and function deviate from those of their cytoskeletal partners, F-actin and microtubules.
Intermediate filament networks show a unique combination of extensibility, flexibility and toughness that confers mechanical resilience to the cell. Vimentin is an intermediate filament protein expressed in mesenchymal cells. This review highlights exciting new results on the physical biology of vimentin intermediate filaments and their role in allowing whole cells and tissues to cope with stress.

Recent advances in synthetic biology-enabled and natural whole-cell optical biosensing of heavy metals

A large number of scientific works have been published on whole-cell heavy metal biosensing based on optical transduction.
The advances in the application of biotechnological tools not only have continuously improved the sensitivity, selectivity, and detection range for biosensors but also have simultaneously unveiled new challenges and restrictions for further improvements. This review highlights selected aspects of whole-cell biosensing of heavy metals using optical transducers.
We have focused on the progress in genetic modulation in regulatory and reporter modules of recombinant plasmids that has enabled the improvement of biosensor performance even if you are looking for the Best Medical Coaching Institute In Dehradun. Simultaneously, an attempt has been made to present newer platforms such as microfluidics that have generated promising results and might give a new turn to the optical biosensing field.

Friends or foes? The knowns and unknowns of natural killer cell biology in COVID-19 and other coronaviruses in July 2020

The COVID-19 pandemic has caused more than 575,000 deaths worldwide as of mid-July 2020 and still continues globally unabated. Immune dysfunction and cytokine storm complicate the disease, which in turn leads to the question of whether stimulation or suppression of the immune system would curb the disease.
Given the varied antiviral and regulatory functions of natural killer (NK) cells, they could be potent and powerful immune allies in this global fight against COVID-19. Unfortunately, there is somewhat limited knowledge of the role of NK cells in SARS-CoV-2 infections and even in the related SARS-CoV-1 and MERS-CoV infections.
Several NK cell therapeutic options already exist in the treatment of tumor and other viral diseases and could be repurposed against COVID-19. In this review, we describe the current understanding and potential roles of NK cells and other Fc receptor (FcR) effector cells in SARS-CoV-2 infection, advantages of using animals to model COVID-19, and NK cell-based therapeutics that are being investigated for COVID-19 therapy.

6X His tag monoclonal antibody

FNSA-0019 500 uL
EUR 341.4
Description: 6X His tag monoclonal antibody secondary antibody

Tetrodotoxin (TTX) ELISA Test Kit

DEIANJ48 96T
EUR 1625
Description: This test kit is for the quantitative detection of Tetrodotoxin in the tissue, liver, fish.

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit

CAS400A-KIT 1 kit (10 rxn)
EUR 1110

PDHE2 protein (GST tag) (His tag)

80-1378 1 mg
EUR 565
Description: PDHE2 protein (GST tag) (His tag)

SLA protein (GST tag) (His tag)

80-1380 1 mg
EUR 597
Description: Purified recombinant SLA protein (GST tag) (His tag)

TROVE2 protein (GST tag) (His tag)

80-1383 1 mg
EUR 619
Description: Purified recombinant TROVE2 (Ro60) protein (GST tag) (His tag)

TSH (Thyrotrophin) ELISA test

14 96T/Box Ask for price
Description: ELISA based test for quantitative detection of TSH (Thyrotrophin)

T3 (Triiodothyronine) ELISA test

15 96T/Box Ask for price
Description: ELISA based test for quantitative detection of T3 (Triiodothyronine)

T4 (Thyroxine) ELISA test

16 96T/Box Ask for price
Description: ELISA based test for quantitative detection of T4 (Thyroxine)

TESTO (Testosterone) ELISA test

19 96T/Box Ask for price
Description: ELISA based test for quantitative detection of O (osterone)

CA72-4 ELISA test

24 96T/Box Ask for price
Description: ELISA based test for quantitative detection of CA72-4

PRL (Prolactin) ELISA test

4 96T/Box Ask for price
Description: ELISA based test for quantitative detection of PRL (Prolactin)

E2 (Estradiol) ELISA test

5 96T/Box Ask for price
Description: ELISA based test for quantitative detection of E2 (Estradiol)

FERR ( Ferritin) ELISA test

7 96T/Box Ask for price
Description: ELISA based test for quantitative detection of FERR ( Ferritin)

HBcAb Sandwich ELISA test

95 96T/Box Ask for price
Description: ELISA based test for quantitative detection of HBcAb Sandwich

PreS2-Ag ELISA test

96 96T/Box Ask for price
Description: ELISA based test for quantitative detection of PreS2-Ag

NDV rapid test kit

RG15-03 1 box
EUR 139.05
Description: Please check the datasheet of NDV rapid test kit before using the test.

Melamine Rapid Test Kit

abx092011-50tests 50 tests
EUR 370

Accu-Tell COVID-19 IgG/IgM Rapid Test

GEN-B352-20tests 20 tests
EUR 236
Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus.

Accu-Tell COVID-19 IgG/IgM Rapid Test

GEN-B352-40tests 40 tests
EUR 321
Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus.

Frit Kit

FRIT-KIT 1each
EUR 124
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

His-tag Purification Kit

abx299036-4U 4 U
EUR 356

DYKDDDDK-Tag Protein ELISA Kit

E4700-100
EUR 436

Column Packing Kit

PACK-KIT 1pack
EUR 1035
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

Myostatin, His-Tag Protein

20-abx262128
  • EUR 328.00
  • EUR 5130.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg

EBNA1 protein (His tag)

80-1340 100 ug
EUR 241
Description: Purified recombinant EBNA1 protein (His tag)

ompP2 protein (His tag)

80-1349 100 ug
EUR 241
Description: Purified recombinant ompP2 protein (His tag)

GARS protein (His tag)

80-1374 1 mg
EUR 565
Description: Purified recombinant GARS/GlyRS protein (His tag)

JO1 protein (His tag)

80-1375 1 mg
EUR 565
Description: Purified recombinant JO1 protein (His tag)

IARS protein (His tag)

80-1377 1 mg
EUR 2120
Description: Purified recombinant IARS (OJ) protein (His tag)

tTG protein (His tag)

80-1379 1 mg
EUR 586
Description: Purified recombinant tTG protein (His tag)

PSIP1 protein (His tag)

80-1381 1 mg
EUR 1753
Description: Purified recombinant PSIP1 (DSF70) protein (His tag)

TPO protein (His tag)

80-1382 1 mg
EUR 1277
Description: Purified recombinant TPO protein (His tag)

TRIM21 protein (His tag)

80-1385 1 mg
EUR 565
Description: Purified recombinant TRIM21 (Ro52) protein (His tag)

TG3 protein (His tag)

80-1386 1 mg
EUR 1321
Description: Purified recombinant Transglutaminase 3 (TG3) protein (His tag)

SP100 protein (His tag)

80-1387 1 mg
EUR 565
Description: Purified recombinant SP100 protein (His tag)

PHGDH protein (His tag)

80-1603 50 ug
EUR 1482
Description: Purified recombinant PHGDH protein (His tag)

HSP90 protein (His tag)

80R-1003 100 ug
EUR 397
Description: Purified recombinant Human HSP90 protein

CEBPalpha protein (His tag)

80R-1005 100 ug
EUR 224
Description: Purified recombinant Human CEBPalpha protein

MIF protein (His tag)

80R-1007 100 ug
EUR 224
Description: Purified recombinant Human MIF protein

TPD52L1 protein (His tag)

80R-1009 100 ug
EUR 397
Description: Purified recombinant Human TPD52L1 protein

HSP70 protein (His tag)

80R-1011 100 ug
EUR 300
Description: Purified recombinant Human HSP70 protein

SNAP25 protein (His tag)

80R-1012 100 ug
EUR 224
Description: Purified recombinant Human SNAP25 protein

BHMT protein (His tag)

80R-1013 100 ug
EUR 224
Description: Purified recombinant Human BHMT protein

DMGO protein (His tag)

80R-1014 100 ug
EUR 224
Description: Purified recombinant Arthrobacter globiformis DMGO protein

PARK7 protein (His tag)

80R-1015 100 ug
EUR 305
Description: Purified recombinant Human PARK7 protein

Geminin protein (His tag)

80R-1016 100 ug
EUR 397
Description: Purified recombinant Human Geminin protein

IRF1 protein (His tag)

80R-1026 100 ug
EUR 305
Description: Purified recombinant Human IRF1 protein

Vaspin protein (His tag)

80R-1027 100 ug
EUR 586
Description: Purified recombinant Human Vaspin protein

Visfatin protein (His tag)

80R-1028 100 ug
EUR 397
Description: Purified recombinant Mouse Visfatin protein

PAI1 protein (His tag)

80R-1029 100 ug
EUR 349
Description: Purified recombinant Human PAI1 protein

FABP1 protein (His tag)

80R-1030 100 ug
EUR 305
Description: Purified recombinant Human FABP1 protein

IRF2 protein (His tag)

80R-1032 100 ug
EUR 397
Description: Purified recombinant Human IRF2 protein

mAdiponectin protein (His tag)

80R-1033 100 ug
EUR 457
Description: Purified recombinant Mouse mAdiponectin protein

IL3 protein (His tag)

80R-1035 100 ug
EUR 397
Description: Purified recombinant Human IL3 protein

IL15 protein (His tag)

80R-1036 100 ug
EUR 397
Description: Purified recombinant Human IL15 protein

BLyS protein (His tag)

80R-1037 100 ug
EUR 397
Description: Purified recombinant Human BLyS protein

RARalpha protein (His tag)

80R-1038 100 ug
EUR 305
Description: Purified recombinant Human RARalpha protein

CIB1 protein (His tag)

80R-1039 100 ug
EUR 305
Description: Purified recombinant Human CIB1 protein

IPP1 protein (His tag)

80R-1040 100 ug
EUR 305
Description: Purified recombinant Human IPP1 protein

HSP60 protein (His tag)

80R-1043 100 ug
EUR 305
Description: Purified recombinant Human HSP60 protein

Visfatin protein (His tag)

80R-1045 100 ug
EUR 305
Description: Purified recombinant Human Visfatin protein

IL16 protein (His tag)

80R-1046 100 ug
EUR 305
Description: Purified recombinant Human IL16 protein

CNTF protein (His tag)

80R-1047 100 ug
EUR 397
Description: Purified recombinant Human CNTF protein

PPID protein (His tag)

80R-1048 100 ug
EUR 397
Description: Purified recombinant Human PPID protein

Nucb2 protein (His tag)

80R-1051 100 ug
EUR 305
Description: Purified recombinant Mouse Nucb2 protein

PPM1G protein (His tag)

80R-1052 100 ug
EUR 224
Description: Purified recombinant Human PPM1G protein

CSTB protein (His tag)

80R-1053 100 ug
EUR 397
Description: Purified recombinant Human CSTB protein

HSF1 protein (His tag)

80R-1054 100 ug
EUR 397
Description: Purified recombinant Human HSF1 protein

Livin protein (His tag)

80R-1056 100 ug
EUR 397
Description: Purified recombinant Human Livin protein

PPP1R14A protein (His tag)

80R-1060 100 ug
EUR 397
Description: Purified recombinant Human PPP1R14A protein

Streptavidin protein (His tag)

80R-1063 100 ug
EUR 305
Description: Purified recombinant Streptomyces avidinii Streptavidin protein

PDPN protein (His tag)

80R-1065 100 ug
EUR 305
Description: Purified recombinant Human PDPN protein

GADD153 protein (His tag)

80R-1068 100 ug
EUR 397
Description: Purified recombinant Human GADD153 protein

BNP protein (His tag)

80R-1069 100 ug
EUR 349
Description: Purified recombinant Human BNP protein

LYVE1 protein (His tag)

80R-1071 50 ug
EUR 586
Description: Purified recombinant Human LYVE1 protein

SIRT6 protein (His tag)

80R-1073 100 ug
EUR 586
Description: Purified recombinant Human SIRT6 protein

MAT2A protein (His tag)

80R-1074 100 ug
EUR 305
Description: Purified recombinant Human MAT2A protein

DHH protein (His tag)

80R-1075 100 ug
EUR 305
Description: Purified recombinant Human DHH protein

PAK4 protein (His tag)

80R-1077 100 ug
EUR 397
Description: Purified recombinant Human PAK4 protein

CRADD protein (His tag)

80R-1078 100 ug
EUR 305
Description: Purified recombinant Human CRADD protein

AK2 protein (His tag)

80R-1079 100 ug
EUR 305
Description: Purified recombinant Human AK2 protein

PPIE protein (His tag)

80R-1080 100 ug
EUR 397
Description: Purified recombinant Human PPIE protein

VAMP8 protein (His tag)

80R-1081 100 ug
EUR 397
Description: Purified recombinant Human VAMP8 protein

VEGF121 protein (His tag)

80R-1082 50 ug
EUR 397
Description: Purified recombinant Human VEGF121 protein

GNMT protein (His tag)

80R-1083 100 ug
EUR 224
Description: Purified recombinant Human GNMT protein

PPIF protein (His tag)

80R-1084 100 ug
EUR 224
Description: Purified recombinant Human PPIF protein

MYL2 protein (His tag)

80R-1085 100 ug
EUR 305
Description: Purified recombinant Human MYL2 protein

UBE2L6 protein (His tag)

80R-1086 100 ug
EUR 397
Description: Purified recombinant Human UBE2L6 protein

GLC8 protein (His tag)

80R-1087 100 ug
EUR 300
Description: Purified recombinant Saccharomyces cerevisiae GLC8 protein

Syntaphilin protein (His tag)

80R-1089 100 ug
EUR 224
Description: Purified recombinant Human Syntaphilin protein

HSPA9 protein (His tag)

80R-1090 100 ug
EUR 224
Description: Purified recombinant Human HSPA9 protein

FGF12 protein (His tag)

80R-1091 100 ug
EUR 586
Description: Purified recombinant Human FGF12 protein

EBAG9 protein (His tag)

80R-1093 100 ug
EUR 224
Description: Purified recombinant Human EBAG9 protein

MGMT protein (His tag)

80R-1094 100 ug
EUR 397
Description: Purified recombinant Human MGMT protein

SMAD4 protein (His tag)

80R-1096 100 ug
EUR 300
Description: Purified recombinant Human SMAD4 protein

SNAPAP protein (His tag)

80R-1097 100 ug
EUR 224
Description: Purified recombinant Human SNAPAP protein

PSMA7 protein (His tag)

80R-1098 100 ug
EUR 224
Description: Purified recombinant Human PSMA7 protein

HSP47 protein (His tag)

80R-1100 100 ug
EUR 224
Description: Purified recombinant Human HSP47 protein

IL10 protein (His tag)

80R-1102 100 ug
EUR 224
Description: Purified recombinant Human IL10 protein

PDK1 protein (His tag)

80R-1103 100 ug
EUR 224
Description: Purified recombinant Human PDK1 protein

NEDD8 protein (His tag)

80R-1104 100 ug
EUR 305
Description: Purified recombinant Human NEDD8 protein

VEGFB protein (His tag)

80R-1106 50 ug
EUR 305
Description: Purified recombinant Human VEGFB protein

BMP7 protein (His tag)

80R-1107 100 ug
EUR 224
Description: Purified recombinant Human BMP7 protein

OSTF1 protein (His tag)

80R-1108 100 ug
EUR 224
Description: Purified recombinant Human OSTF1 protein

FGF21 protein (His tag)

80R-1109 100 ug
EUR 224
Description: Purified recombinant Human FGF21 protein

IL4 protein (His tag)

80R-1111 50 ug
EUR 586
Description: Purified recombinant Human IL4 protein

IL32 protein (His tag)

80R-1113 100 ug
EUR 349
Description: Purified recombinant Human IL32 protein

Dkk1 protein (His tag)

80R-1115 10 ug
EUR 365
Description: Purified recombinant Human Dkk1 protein

AKR1C3 protein (His tag)

80R-1116 100 ug
EUR 305
Description: Purified recombinant Human AKR1C3 protein

IL18 protein (His tag)

80R-1117 100 ug
EUR 305
Description: Purified recombinant Human IL18 protein

HNMT protein (His tag)

80R-1118 100 ug
EUR 305
Description: Purified recombinant Human HNMT protein

Osteopontin protein (His tag)

80R-1119 100 ug
EUR 586
Description: Purified recombinant Human Osteopontin protein

PSMB1 protein (His tag)

80R-1120 100 ug
EUR 586
Description: Purified recombinant Human PSMB1 protein

HSP90B1 protein (His tag)

80R-1121 100 ug
EUR 673
Description: Purified recombinant Human HSP90B1 protein

Dysbindin protein (His tag)

80R-1122 100 ug
EUR 397
Description: Purified recombinant Human Dysbindin protein

Stathmin protein (His tag)

80R-1123 100 ug
EUR 305
Description: Purified recombinant Human Stathmin protein

GRB2 protein (His tag)

80R-1127 100 ug
EUR 305
Description: Purified recombinant Human GRB2 protein

SPG21 protein (His tag)

80R-1128 100 ug
EUR 305
Description: Purified recombinant Human SPG21 protein

IL15 protein (His tag)

80R-1131 50 ug
EUR 305
Description: Purified recombinant Mouse IL15 protein

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