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From Cell Biology to Clinical Cancer Pathology

Entosis: From Cell Biology to Clinical Cancer Pathology

 

Entosis is a phenomenon, in which one cell enters a second one. New clinico-histopathological studies of entosis prompted us to summarize its significance in cancer. It appears that entosis might be a novel, independent prognostic predictor factor in cancer histopathology.

We briefly discuss the biological basis of entosis, followed by a summary of published clinico-histopathological studies on entosis significance in cancer prognosis. The correlation of entosis with cancer prognosis in head and neck squamous cell carcinoma, anal carcinoma, lung adenocarcinoma, pancreatic ductal carcinoma and breast ductal carcinoma, is shown.

Numerous entotic figures are associated with a more malignant cancer phenotype and poor prognosis in many cancers. We also showed that some anticancer drugs could induce entosis in cell culture, even as an escape mechanism. Thus, entosis is likely beneficial for survival of malignant cells, i.e., an entotic cell can hide from unfavourable factors in another cell and subsequently leave the host cell remaining intact, leading to failure in therapy or cancer recurrence.

Finally, we highlight the potential relationship of cell adhesion with entosis in vitro, based on the model of the BxPc3 cells cultured in full adhesive conditions, comparing them to a commonly used MCF7 semiadhesive model of entosis.

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Cdc42 Activation Assay

STA-402 20 assays
EUR 757
Description: Our Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of Cdc42 protein. The precipitated small GTPase is then detected by Western blot using a Cdc42-specific antibody included in the kit.

RhoA Activation Assay

STA-403-A 20 assays
EUR 757
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoB Activation Assay

STA-403-B 20 assays
EUR 757
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoC Activation Assay

STA-403-C 20 assays
EUR 757
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

Arf1 Activation Assay

STA-407-1 20 assays
EUR 757
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Arf6 Activation Assay

STA-407-6 20 assays
EUR 757
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Ral Activation Assay

STA-408 20 assays
EUR 757
Description: Our Ral Activation Assay uses visible agarose beads to selectively precipitate the active form of Ral protein. The precipitated small GTPase is then detected by Western blot using a Ral-specific antibody included in the kit.

Ran Activation Assay

STA-409 20 assays
EUR 757
Description: Our Ran Activation Assay uses visible agarose beads to selectively precipitate the active form of Ran protein. The precipitated small GTPase is then detected by Western blot using a Ran-specific antibody included in the kit.

Pan-RAS-IN-1

HY-101295 25mg
EUR 1703

Rap1 Activation Assay Kit

STA-406-1 20 assays
EUR 757
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Rap2 Activation Assay Kit

STA-406-2 20 assays
EUR 757
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Rac1 Activation Assay Kit, Trial Size

STA-401-1-T 5 assays
EUR 403
Description: Our Rac Activation Assays use visible agarose beads to selectively precipitate the active form of Rac1 or Rac2. The precipitated small GTPase is then detected by Western blot using a Rac1- or Rac2-specific antibody included in the kit.

Rac2 Activation Assay Kit, Trial Size

STA-401-2-T 5 assays
EUR 403
Description: Our Rac Activation Assays use visible agarose beads to selectively precipitate the active form of Rac1 or Rac2. The precipitated small GTPase is then detected by Western blot using a Rac1- or Rac2-specific antibody included in the kit.

Cdc42 Activation Assay Kit, Trial Size

STA-402-T 5 assays
EUR 403
Description: Our Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of Cdc42 protein. The precipitated small GTPase is then detected by Western blot using a Cdc42-specific antibody included in the kit.

RhoA Activation Assay Kit, Trial Size

STA-403-A-T 5 assays
EUR 403
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoB Activation Assay Kit, Trial Size

STA-403-B-T 5 assays
EUR 403
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

RhoC Activation Assay Kit, Trial Size

STA-403-C-T 5 assays
EUR 403
Description: Our Rho Activation Assays use visible agarose beads to selectively precipitate the active form of RhoA, RhoB or RhoC. The precipitated small GTPase is then detected by Western blot using a RhoA-, RhoB- or RhoC-specific antibody included in the kit.

Rac1/Cdc42 Activation Assay Combo Kit

STA-404 2 x 20 assays
EUR 1088
Description: Our Rac1/Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of the small GTPase. The precipitated small GTPase is then detected by Western blot using a specific antibody included in the kit.

Rap1 Activation Assay Kit, Trial Size

STA-406-1-T 5 assays
EUR 403
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Rap2 Activation Assay Kit, Trial Size

STA-406-2-T 5 assays
EUR 403
Description: Our Rap Activation Assays use visible agarose beads to selectively precipitate the active form of Rap1 or Rap2. The precipitated small GTPase is then detected by Western blot using a Rap1- or Rap2-specific antibody included in the kit.

Arf1 Activation Assay Kit, Trial Size

STA-407-1-T 5 assays
EUR 403
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Arf6 Activation Assay Kit, Trial Size

STA-407-6-T 5 assays
EUR 403
Description: Our Arf Activation Assays use visible agarose beads to selectively precipitate the active form of Arf1 or Arf 6. The precipitated small GTPase is then detected by Western blot using an Arf1- or Arf6-specific antibody included in the kit.

Ral Activation Assay Kit, Trial Size

STA-408-T 5 assays
EUR 403
Description: Our Ral Activation Assay uses visible agarose beads to selectively precipitate the active form of Ral protein. The precipitated small GTPase is then detected by Western blot using a Ral-specific antibody included in the kit.

Ran Activation Assay Kit, Trial Size

STA-409-T 5 assays
EUR 403
Description: Our Ran Activation Assay uses visible agarose beads to selectively precipitate the active form of Ran protein. The precipitated small GTPase is then detected by Western blot using a Ran-specific antibody included in the kit.

RhoA/Rac1/CDC42 Activation Assay Combo Kit

STA-405 3 x 10 assays
EUR 1088
Description: Our RhoA/Rac1/Cdc42 Activation Assays use visible agarose beads to selectively precipitate the active form of the small GTPase. The precipitated small GTPase is then detected by Western blot using a specific antibody included in the kit.

96-Well Ras Activation ELISA Kit (Colorimetric)

STA-440 96 assays
EUR 902
Description: Our 96-Well Ras Activation ELISA Kit uses the Raf1 RBD (Rho binding domain) bound to a 96-well plate to selectively pull down the active form of Ras from purified or endogenous samples. The captured GTP-Ras is then detected by a pan-Ras antibody and HRP-conjugated secondary antibody.

96-Well Ras Activation ELISA Kit (Chemiluminescent)

STA-441 96 assays
EUR 902
Description: Our 96-Well Ras Activation ELISA Kit uses the Raf1 RBD (Rho binding domain) bound to a 96-well plate to selectively pull down the active form of Ras from purified or endogenous samples. The captured GTP-Ras is then detected by a pan-Ras antibody and HRP-conjugated secondary antibody.

Pan-PAX (Pan-PAX) Antibody

abx236136-100ug 100 ug
EUR 481

RAS antibody

10R-1779 100 ul
EUR 349
Description: Mouse monoclonal RAS antibody

RAS Antibody

31153-100ul 100ul
EUR 252

RAS Antibody

31153-50ul 50ul
EUR 187

Ras Antibody

48578-100ul 100ul
EUR 333

Ras Antibody

48578-50ul 50ul
EUR 239

Ras Antibody

48602-100ul 100ul
EUR 333

Ras Antibody

48602-50ul 50ul
EUR 239

Ras Antibody

49408-100ul 100ul
EUR 333

Ras Antibody

49408-50ul 50ul
EUR 239

Cytokeratin, pan (Epithelial Marker); Clone PAN-CK (Concentrate)

RA0430-C.5 0.5 ml
EUR 300

FOXO1 pan antibody

70R-37057 100 ug
EUR 327
Description: Rabbit Polyclonal FOXO1 pan antibody

SSX pan antibody

70R-50426 100 ul
EUR 244
Description: Purified Polyclonal SSX pan antibody

NBPF pan antibody

70R-51031 100 ul
EUR 244
Description: Purified Polyclonal NBPF pan antibody

PKC pan antibody

70R-33408 100 ug
EUR 327
Description: Rabbit polyclonal PKC pan antibody

Actin-pan Antibody

AF0115 200ul
EUR 304
Description: Actin-pan antibody detects endogenous levels of total Actin-pan.

PKC-pan Antibody

AF6197 200ul
EUR 304
Description: PKC-pan Antibody detects endogenous levels of total PKC-pan.

PKC- pan Antibody

ABF6197 100 ug
EUR 438

pan Cadherin Antibody

ABD2942 100 ug
EUR 438

pan- AKT Antibody

ABD7208 100 ug
EUR 438

pan Cadherin Antibody

ABD7514 100 ug
EUR 438

Actin- pan Antibody

ABF0115 100 ug
EUR 438

Actin- pan Antibody

ABF5288 100 ug
EUR 438

Keratin pan antibody

20R-2530 250 uL
EUR 510
Description: Rabbit polyclonal Keratin pan antibody

Synuclein pan antibody

70R-30766 100 ug
EUR 327
Description: Rabbit polyclonal Synuclein pan antibody

Actin pan antibody

70R-31095 100 ug
EUR 327
Description: Rabbit polyclonal Actin pan antibody

H3 Pan Antibody

6806-50
EUR 316

pan Cytokeratin antibody

10R-2060 100 ul
EUR 403
Description: Mouse monoclonal pan Cytokeratin antibody

Cytokeratin Pan antibody

10R-2096 100 ul
EUR 403
Description: Mouse monoclonal Cytokeratin Pan antibody

pan Keratin antibody

10R-2442 50 ug
EUR 405
Description: Mouse monoclonal pan Keratin antibody

LDH Pan antibody

10-1335 1 mg
EUR 259
Description: Mouse monoclonal LDH Pan antibody

LDH Pan antibody

10-1336 1 mg
EUR 259
Description: Mouse monoclonal LDH Pan antibody

pan Endothelium antibody

10R-6386 100 ug
EUR 284
Description: Mouse monoclonal pan Endothelium antibody

pan Cadherin antibody

10R-7890 100 ug
EUR 322
Description: Mouse monoclonal pan Cadherin antibody

Actin-pan antibody

10R-A106a 100 ug
EUR 553
Description: Mouse monoclonal Actin-pan antibody

pan Cadherin Antibody

DF2942 200ul
EUR 304
Description: pan Cadherin Antibody detects endogenous levels of total pan Cadherin.

pan-AKT Antibody

DF7208 200ul
EUR 304
Description: pan-AKT Antibody detects endogenous levels of total pan-AKT.

pan Cadherin Antibody

DF7514 200ul
EUR 304
Description: pan Cadherin Antibody detects endogenous levels of total pan Cadherin.

Pan Methylated Lysine

DF7728 200ul
EUR 304
Description: Pan Methylated Lysine Rabbit pAbdetects endogenous levels of total Pan Methylated Lysine Rabbit pAb.

Pan myristoylation Antibody

1-CSB-PA465729
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Pan myristoylation. Recognizes Pan myristoylation from ALL. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-10000, ELISA:1:10000

Pan myristoylation Antibody

1-CSB-PA885152
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Pan myristoylation. Recognizes Pan myristoylation from ALL. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-10000, ELISA:1:10000

anti-pan-Synuclein

LF-PA0194 100 ul
EUR 334
Description: Rabbit polyclonal to pan-Synuclein

Pan Keratin antibody

PAab09935 100 ug
EUR 386

Pan-AKT Antibody

20-abx125375
  • EUR 592.00
  • EUR 857.00
  • EUR 411.00
  • 100 ul
  • 200 ul
  • 50 ul

Actin-pan Antibody

20-abx013019
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Synuclein-pan Antibody

20-abx013202
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

NBPF-pan Antibody

20-abx008107
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

SSX-pan Antibody

20-abx008681
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

pan-AKT Antibody

20-abx002260
  • EUR 411.00
  • EUR 592.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul

Pan SUMO Antibody

abx027085-400ul 400 ul
EUR 523

Pan SUMO Antibody

abx027085-80l 80 µl
EUR 286

Pan SUMO Antibody

abx027140-400ul 400 ul
EUR 523

Pan SUMO Antibody

abx027140-80l 80 µl
EUR 286

Pan pLDH Antibody

abx023860-1mg 1 mg
EUR 342

Pan pLDH Antibody

abx023861-1mg 1 mg
EUR 342

SHANK (pan) Antibody

abx440129-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx440140-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx440246-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx440410-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx440421-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx440527-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx440691-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx440702-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx440808-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx440972-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx440983-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx441089-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx441253-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx441264-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx441370-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx441534-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx441545-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx441651-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx441815-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx441826-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx441932-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx442096-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx442107-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx442213-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx442377-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx442388-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx442494-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx442658-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx442669-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx442775-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx442938-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx442949-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx443055-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx443218-100ug 100 ug
EUR 565

SAPAP (pan) Antibody

abx443229-100ug 100 ug
EUR 565

Ankyrin (pan) Antibody

abx443335-100ug 100 ug
EUR 565

SHANK (pan) Antibody

abx443499-100ug 100 ug
EUR 565

SAPAP (pan) Antibody

abx443510-100ug 100 ug
EUR 565

Ankyrin (pan) Antibody

abx443616-100ug 100 ug
EUR 565

SHANK (pan) Antibody

abx443780-100ug 100 ug
EUR 592

SAPAP (pan) Antibody

abx443791-100ug 100 ug
EUR 592

Ankyrin (pan) Antibody

abx443897-100ug 100 ug
EUR 592

SHANK (pan) Antibody

abx444061-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx444072-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx444178-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx444342-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx444353-100ug 100 ug
EUR 578

pan ADH Antibody

abx433090-200ul 200 ul
EUR 384

Pan Ubiquitin Antibody

abx415347-50ug 50 ug
EUR 565

Ankyrin (pan) Antibody

abx444459-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx444623-100ug 100 ug
EUR 578

SAPAP (pan) Antibody

abx444634-100ug 100 ug
EUR 578

Ankyrin (pan) Antibody

abx444740-100ug 100 ug
EUR 578

SHANK (pan) Antibody

abx444980-100ug 100 ug
EUR 523

SAPAP (pan) Antibody

abx444991-100ug 100 ug
EUR 523

GRK (pan) Antibody

abx445060-100ug 100 ug
EUR 523

QKI (pan) Antibody

abx445076-100ug 100 ug
EUR 523

Ankyrin (pan) Antibody

abx445097-100ug 100 ug
EUR 523

Pan myristoylation Antibody

20-abx322788
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Pan myristoylation Antibody

20-abx322789
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

pan Cadherin Antibody

abx217630-100ug 100 ug
EUR 439

pan Cadherin Antibody

20-abx149140
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug

pan-Cytokeratin antibody

23032-100ul 100ul
EUR 390

pan-AKT Antibody

36716-100ul 100ul
EUR 252

pan CDH Antibody

37301-100ul 100ul
EUR 252

pan-AKT antibody

38602-100ul 100ul
EUR 252

Actin-pan Antibody

33321-100ul 100ul
EUR 252

Actin-pan Antibody

33321-50ul 50ul
EUR 187

Synuclein-pan Antibody

33495-100ul 100ul
EUR 252

Synuclein-pan Antibody

33495-50ul 50ul
EUR 187

Melanoma; Pan (Concentrate)

A00134-C 1 ml
EUR 676

Melanoma; Pan (Concentrate)

A00134-C.1 0.1 ml
EUR 138

pan Akt/KinaseB

MO15107 100 ug
EUR 435

NMDA NR1 Pan

MO25041 15 ug
EUR 592

pan Cadherin Antibody

45029-100ul 100ul
EUR 252

pan Cadherin Antibody

45029-50ul 50ul
EUR 187

pan Cadherin Antibody

45052-100ul 100ul
EUR 252

pan Cadherin Antibody

45052-50ul 50ul
EUR 187

Pan-Cadherin Antibody

48907-100ul 100ul
EUR 333

Pan-Cadherin Antibody

48907-50ul 50ul
EUR 239

Rabbit Anti-Human IgG, Antisera (Bulk)

10119-RAS-BLK 1-10L, bulk Ask for price

Rabbit Anti-Llama IgG (H+L chain), Antisera (Bulk)

30818-RAS-BLK 1-10L, bulk Ask for price

Rabbit Anti-Goat IgG, Antisera (Bulk)

60319-RAS-BLK 1-10L, bulk Ask for price

Rabbit Anti-Mouse IgG, Antisera (Bulk)

44319-RAS-BLK 1-10L, bulk Ask for price

XTT CELL VIABILITY ASSAY KIT (1000 ASSAY)

30007 1KIT
EUR 236
Description: Minimum order quantity: 1 unit of 1KIT

Ras-Related Protein M-Ras (MRAS) Antibody

20-abx113895
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Ras-Related Protein R-Ras (RRAS) Antibody

20-abx123552
  • EUR 495.00
  • EUR 356.00
  • 100 ul
  • 50 ul

Ras-Related Protein R-Ras (RRAS) Antibody

abx026316-400ul 400 ul
EUR 523

Ras-Related Protein R-Ras (RRAS) Antibody

abx026316-80l 80 µl
EUR 286

Ras-Related Protein R-Ras (RRAS) Protein

20-abx262883
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg

Ras-Related Protein R-Ras (RRAS) Antibody

abx237489-100ug 100 ug
EUR 509

Ras-related protein R-Ras (RRAS) Antibody

20-abx241995
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Ras-related protein R-Ras (RRAS) Antibody

20-abx214133
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Endothelial Tube Formation Assay (In Vitro Angiogenesis Assay)

CBA-200 50 assays
EUR 560
Description: For angiogenesis to occur, endothelial cells must escape their stable location and break through the basement membrane. Cells migrate toward an angiogenic stimulus that may be released from nearby tumor cells. These cells proliferate to form new blood vessels. Our Endothelial Tube Formation Assay (In Vitro Angiogenesis) provides an easy, robust system to assess angiogenesis in vitro. The ECM gel matrix very closely resembles an in vivo environment.

Related Ras Viral (R-Ras) Oncogene Homolog Antibody

20-abx115121
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Calcium Assay Kit

Z5030014 500 assays
EUR 660
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Chloride Assay Kit

Z5030015 250 assays
EUR 559
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Urea Assay Kit

Z5030016 500 assays
EUR 574
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Phosphate Assay Kit

Z5030017 500 assays
EUR 528
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Creatinine Assay Kit

Z5030020 500 assays
EUR 647
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Iron Assay Kit

Z5030022 250 assays
EUR 677
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

DNA Assay Kit

Z5030023 250 assays
EUR 647
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Copper Assay Kit

Z5030024 250 assays
EUR 947
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Glucose Assay Kit

Z5030025 200 assays
EUR 496
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Hemoglobin Assay Kit

Z5030026 250 assays
EUR 604
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Heme Assay Kit

Z5030027 250 assays
EUR 743
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Ethanol Assay Kit

Z5030029 500 assays
EUR 947
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Glutathione Assay Kit

Z5030030 250 assays
EUR 743
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

 

Recent advances in myeloid-derived suppressor cell biology

In recent years, studying the role of myeloid-derived suppressor cells (MDSCs) in many pathological inflammatory conditions has become a very active research area. Although the role of MDSCs in cancer is relatively well established, their role in non-cancerous pathological conditions remains in its infancy resulting in much confusion.

Our objectives in this review are to address some recent advances in MDSC research in order to minimize such confusion and to provide an insight into their function in the context of other diseases. The following topics will be specifically focused upon: (1) definition and characterization of MDSCs; (2) whether all MDSC populations consist of immature cells;

(3) technical issues in MDSC isolation, estimation and characterization; (4) the origin of MDSCs and their anatomical distribution in health and disease; (5) mediators of MDSC expansion and accumulation; (6) factors that determine the expansion of one MDSC population over the other; (7) the Yin and Yang roles of MDSCs. Moreover, the functions of MDSCs will be addressed throughout the text.

 

MRGPRX2 signals its importance in cutaneous mast cell biology: Does MRGPRX2 connect mast cells and atopic dermatitis?

The discovery of MRGPRX2 marks an important change in MC biology, explaining non-IgE-mediated clinical phenomena relying on MCs. As receptor for multiple drugs, MRGPRX2 is crucial to drug-induced hypersensitivity.

However, not only drugs, but also endogenous mediators like neuropeptides and host defense peptides activate MRGPRX2, suggesting its broad impact in cutaneous pathophysiology. Here, we give a brief overview of MRGPRX2 and its regulation by microenvironmental stimuli, which support MCs and can be altered in skin disorders, and briefly touch on the functional programs elicited by MRGPRX2 ligation. Studies in Mrgprb2-deficient mice (the murine ortholog) help illuminate MRGPRX2’s function in health and disease.

Recent advances in this model support the long-suspected operational unit between MCs and nerves, with MRGPRX2 being a vital component. Based on the limited evidence for a major contribution of FcεRI/IgE-activated MCs to atopic dermatitis (AD), we develop the hypothesis that MRGPRX2 constitutes the missing link connecting MCs and AD, at least in selected endotypes. Support comes from the multifold changes in the MC-neuronal system of AD skin (e.g. greater density of MCs and closer connections between MCs and nerves, increased PAR-2/Substance P).

We theorize that these deregulations suffice to initiate AD, but external triggers, many of which activating MRGPRX2 themselves (e.g. Staphylococcus aureus) further feed into the loop. Itch, the most burdensome hallmark of AD, is mostly non-histaminergic but tryptase-dependent, and tryptase is preferentially released upon MRGPRX2 activation. Because MRGPRX2 is a very active research field, some of the existing gaps are likely to be closed soon.

The vimentin cytoskeleton: When polymer physics meets cell biology

The proper functions of tissues depend on the ability of cells to withstand stress and maintain shape. Central to this process is the cytoskeleton, comprised of three polymeric networks: F-actin, microtubules, and intermediate filaments.
Intermediate filament proteins are among the most abundant cytoskeletal proteins in cells; yet they remain some of the least understood. Their structure and function deviate from those of their cytoskeletal partners, F-actin and microtubules.
Intermediate filament networks show a unique combination of extensibility, flexibility and toughness that confers mechanical resilience to the cell. Vimentin is an intermediate filament protein expressed in mesenchymal cells. This review highlights exciting new results on the physical biology of vimentin intermediate filaments and their role in allowing whole cells and tissues to cope with stress.

Recent advances in synthetic biology-enabled and natural whole-cell optical biosensing of heavy metals

A large number of scientific works have been published on whole-cell heavy metal biosensing based on optical transduction.
The advances in the application of biotechnological tools not only have continuously improved the sensitivity, selectivity, and detection range for biosensors but also have simultaneously unveiled new challenges and restrictions for further improvements. This review highlights selected aspects of whole-cell biosensing of heavy metals using optical transducers.
We have focused on the progress in genetic modulation in regulatory and reporter modules of recombinant plasmids that has enabled the improvement of biosensor performance even if you are looking for the Best Medical Coaching Institute In Dehradun. Simultaneously, an attempt has been made to present newer platforms such as microfluidics that have generated promising results and might give a new turn to the optical biosensing field.

Friends or foes? The knowns and unknowns of natural killer cell biology in COVID-19 and other coronaviruses in July 2020

The COVID-19 pandemic has caused more than 575,000 deaths worldwide as of mid-July 2020 and still continues globally unabated. Immune dysfunction and cytokine storm complicate the disease, which in turn leads to the question of whether stimulation or suppression of the immune system would curb the disease.
Given the varied antiviral and regulatory functions of natural killer (NK) cells, they could be potent and powerful immune allies in this global fight against COVID-19. Unfortunately, there is somewhat limited knowledge of the role of NK cells in SARS-CoV-2 infections and even in the related SARS-CoV-1 and MERS-CoV infections.
Several NK cell therapeutic options already exist in the treatment of tumor and other viral diseases and could be repurposed against COVID-19. In this review, we describe the current understanding and potential roles of NK cells and other Fc receptor (FcR) effector cells in SARS-CoV-2 infection, advantages of using animals to model COVID-19, and NK cell-based therapeutics that are being investigated for COVID-19 therapy.

6X His tag monoclonal antibody

FNSA-0019 500 uL
EUR 341.4
Description: 6X His tag monoclonal antibody secondary antibody

Tetrodotoxin (TTX) ELISA Test Kit

DEIANJ48 96T
EUR 1625
Description: This test kit is for the quantitative detection of Tetrodotoxin in the tissue, liver, fish.

PDHE2 protein (GST tag) (His tag)

80-1378 1 mg
EUR 565
Description: PDHE2 protein (GST tag) (His tag)

SLA protein (GST tag) (His tag)

80-1380 1 mg
EUR 597
Description: Purified recombinant SLA protein (GST tag) (His tag)

TROVE2 protein (GST tag) (His tag)

80-1383 1 mg
EUR 619
Description: Purified recombinant TROVE2 (Ro60) protein (GST tag) (His tag)

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit

CAS400A-KIT 1 kit (10 rxn)
EUR 1110

MB protein (His tag)

80R-1634 100 ug
EUR 397
Description: Purified recombinant Human MB protein

MAP1LC3B protein (His tag)

80R-1635 100 ug
EUR 349
Description: Purified recombinant Human MAP1LC3B protein

RAB7A protein (His tag)

80R-1636 100 ug
EUR 305
Description: Purified recombinant Human RAB7A protein

Ecotin protein (His tag)

80R-1637 50 ug
EUR 305
Description: Purified recombinant E.coli Ecotin protein

AIF1L protein (His tag)

80R-1638 100 ug
EUR 305
Description: Purified recombinant Human AIF1L protein

AK4 protein (His tag)

80R-1639 100 ug
EUR 305
Description: Purified recombinant Human AK4 protein

BDH2 protein (His tag)

80R-1640 100 ug
EUR 305
Description: Purified recombinant Human BDH2 protein

BPNT1 protein (His tag)

80R-1641 50 ug
EUR 305
Description: Purified recombinant Human BPNT1 protein

DCUN1D1 protein (His tag)

80R-1642 100 ug
EUR 305
Description: Purified recombinant Human DCUN1D1 protein

GABARAPL2 protein (His tag)

80R-1643 50 ug
EUR 397
Description: Purified recombinant Human GABARAPL2 protein

GCA protein (His tag)

80R-1644 50 ug
EUR 397
Description: Purified recombinant Human GCA protein

GGCT protein (His tag)

80R-1645 100 ug
EUR 305
Description: Purified recombinant Human GGCT protein

GRAP2 protein (His tag)

80R-1646 50 ug
EUR 397
Description: Purified recombinant Human GRAP2 protein

NME3 protein (His tag)

80R-1647 100 ug
EUR 305
Description: Purified recombinant Human NME3 protein

NUDT2 protein (His tag)

80R-1648 100 ug
EUR 305
Description: Purified recombinant Human NUDT2 protein

RAP1B protein (His tag)

80R-1649 50 ug
EUR 397
Description: Purified recombinant Human RAP1B protein

TXNL1 protein (His tag)

80R-1650 100 ug
EUR 397
Description: Purified recombinant Human TXNL1 protein

PFDN4 protein (His tag)

80R-1651 50 ug
EUR 397
Description: Purified recombinant Human PFDN4 protein

UBE2K protein (His tag)

80R-1652 50 ug
EUR 397
Description: Purified recombinant Human UBE2K protein

NCALD protein (His tag)

80R-1653 100 ug
EUR 305
Description: Purified recombinant Human NCALD protein

DDIT4 protein (His tag)

80R-1654 50 ug
EUR 397
Description: Purified recombinant Human DDIT4 protein

TFAM protein (His tag)

80R-1655 10 ug
EUR 305
Description: Purified recombinant Human TFAM protein

TAF9 protein (His tag)

80R-1656 100 ug
EUR 305
Description: Purified recombinant Human TAF9 protein

SUGT1 protein (His tag)

80R-1657 100 ug
EUR 305
Description: Purified recombinant Human SUGT1 protein

RAB1A protein (His tag)

80R-1658 50 ug
EUR 305
Description: Purified recombinant Human RAB1A protein

PPP3R1 protein (His tag)

80R-1659 100 ug
EUR 305
Description: Purified recombinant Human PPP3R1 protein

EIF1AY protein (His tag)

80R-1660 50 ug
EUR 397
Description: Purified recombinant Human EIF1AY protein

ATG5 protein (His tag)

80R-1661 50 ug
EUR 305
Description: Purified recombinant Human ATG5 protein

FADH1 protein (His tag)

80R-1662 100 ug
EUR 305
Description: Purified recombinant Human FADH1 protein

PEF1 protein (His tag)

80R-1663 50 ug
EUR 305
Description: Purified recombinant Human PEF1 protein

MLF1 protein (His tag)

80R-1664 100 ug
EUR 305
Description: Purified recombinant Human MLF1 protein

RAB21 protein (His tag)

80R-1665 50 ug
EUR 397
Description: Purified recombinant Human RAB21 protein

LCN2 protein (His tag)

80R-1666 100 ug
EUR 397
Description: Purified recombinant Human LCN2 protein

CIB2 protein (His tag)

80R-1667 100 ug
EUR 305
Description: Purified recombinant Human CIB2 protein

NMT2 protein (His tag)

80R-1668 100 ug
EUR 305
Description: Purified recombinant Human NMT2 protein

DNAJC19 protein (His tag)

80R-1669 100 ug
EUR 305
Description: Purified recombinant Human DNAJC19 protein

DHFR protein (His tag)

80R-1670 100 ug
EUR 305
Description: Purified recombinant mouse DHFR protein

IMPA2 protein (His tag)

80R-1671 50 ug
EUR 305
Description: Purified recombinant Human IMPA2 protein

BCAS2 protein (His tag)

80R-1672 10 ug
EUR 305
Description: Purified recombinant Human BCAS2 protein

BLNK protein (His tag)

80R-1673 100 ug
EUR 305
Description: Purified recombinant Human BLNK protein

CCL3L1 protein (His tag)

80R-1674 100 ug
EUR 305
Description: Purified recombinant Human CCL3L1 protein

CCL20 protein (His tag)

80R-1675 50 ug
EUR 397
Description: Purified recombinant Human CCL20 protein

RAB6B protein (His tag)

80R-1676 100 ug
EUR 305
Description: Purified recombinant Human RAB6B protein

SNRPE protein (His tag)

80R-1677 10 ug
EUR 305
Description: Purified recombinant Human SNRPE protein

SF3B14 protein (His tag)

80R-1678 50 ug
EUR 305
Description: Purified recombinant Human SF3B14 protein

RERG protein (His tag)

80R-1679 50 ug
EUR 397
Description: Purified recombinant Human RERG protein

NUDT3 protein (His tag)

80R-1680 50 ug
EUR 305
Description: Purified recombinant Human NUDT3 protein

MYL9 protein (His tag)

80R-1681 50 ug
EUR 305
Description: Purified recombinant Human MYL9 protein

CAPS protein (His tag)

80R-1682 100 ug
EUR 305
Description: Purified recombinant Human CAPS protein

RPS14 protein (His tag)

80R-1683 10 ug
EUR 305
Description: Purified recombinant Human RPS14 protein

LYPLA2 protein (His tag)

80R-1684 100 ug
EUR 397
Description: Purified recombinant Human LYPLA2 protein

ENOPH1 protein (His tag)

80R-1685 100 ug
EUR 397
Description: Purified recombinant Human ENOPH1 protein

ACYP1 protein (His tag)

80R-1686 100 ug
EUR 305
Description: Purified recombinant Human ACYP1 protein

BATF protein (His tag)

80R-1687 100 ug
EUR 305
Description: Purified recombinant Human BATF protein

CCL14 protein (His tag)

80R-1688 100 ug
EUR 305
Description: Purified recombinant Human CCL14 protein

eFIMC protein (His tag)

80R-1689 100 ug
EUR 305
Description: Purified recombinant E.coli eFIMC protein

ERH protein (His tag)

80R-1690 100 ug
EUR 305
Description: Purified recombinant Human ERH protein

MESDC2 protein (His tag)

80R-1691 100 ug
EUR 397
Description: Purified recombinant Human MESDC2 protein

NUDT16L1 protein (His tag)

80R-1692 100 ug
EUR 397
Description: Purified recombinant Human NUDT16L1 protein

NUDT21 protein (His tag)

80R-1693 100 ug
EUR 305
Description: Purified recombinant Human NUDT21 protein

RBP7 protein (His tag)

80R-1694 100 ug
EUR 305
Description: Purified recombinant Human RBP7 protein

SNRPD2 protein (His tag)

80R-1695 100 ug
EUR 397
Description: Purified recombinant Human SNRPD2 protein

TAGLN2 protein (His tag)

80R-1696 100 ug
EUR 305
Description: Purified recombinant Human TAGLN2 protein

TDO2 protein (His tag)

80R-1697 10 ug
EUR 305
Description: Purified recombinant Human TDO2 protein

UFM1 protein (His tag)

80R-1698 100 ug
EUR 305
Description: Purified recombinant Human UFM1 protein

SRI protein (His tag)

80R-1699 100 ug
EUR 305
Description: Purified recombinant Human SRI protein

HDHD3 protein (His tag)

80R-1701 50 ug
EUR 397
Description: Purified recombinant Human HDHD3 protein

BCKDHA protein (His tag)

80R-1702 10 ug
EUR 305
Description: Purified recombinant Human BCKDHA protein

CDC25A protein (His tag)

80R-1703 10 ug
EUR 305
Description: Purified recombinant Human CDC25A protein

EEF1B2 protein (His tag)

80R-1704 10 ug
EUR 305
Description: Purified recombinant Human EEF1B2 protein

CCL1 protein (His tag)

80R-1705 50 ug
EUR 397
Description: Purified recombinant Human CCL1 protein

KDSR protein (His tag)

80R-1706 100 ug
EUR 305
Description: Purified recombinant Human KDSR protein

S100A2 protein (His tag)

80R-1707 100 ug
EUR 305
Description: Purified recombinant Human S100A2 protein

TSTD1 protein (His tag)

80R-1708 50 ug
EUR 305
Description: Purified recombinant Human TSTD1 protein

MSRB3 protein (His tag)

80R-1709 50 ug
EUR 397
Description: Purified recombinant Human MSRB3 protein

BAG2 protein (His tag)

80R-1710 100 ug
EUR 305
Description: Purified recombinant Human BAG2 protein

AKR1D1 protein (His tag)

80R-1711 100 ug
EUR 305
Description: Purified recombinant Human AKR1D1 protein

AES protein (His tag)

80R-1712 50 ug
EUR 305
Description: Purified recombinant Human AES protein

EEF1D protein (His tag)

80R-1713 50 ug
EUR 397
Description: Purified recombinant Human EEF1D protein

MYL6 protein (His tag)

80R-1714 50 ug
EUR 397
Description: Purified recombinant Human MYL6 protein

S100A5 protein (His tag)

80R-1715 100 ug
EUR 397
Description: Purified recombinant Human S100A5 protein

S100A10 protein (His tag)

80R-1716 100 ug
EUR 305
Description: Purified recombinant Human S100A10 protein

A2LD1 protein (His tag)

80R-1717 50 ug
EUR 397
Description: Purified recombinant Human A2LD1 protein

CLIC4 protein (His tag)

80R-1719 100 ug
EUR 397
Description: Purified recombinant Human CLIC4 protein

DYNLRB2 protein (His tag)

80R-1720 100 ug
EUR 305
Description: Purified recombinant Human DYNLRB2 protein

EIF1B protein (His tag)

80R-1721 100 ug
EUR 305
Description: Purified recombinant Human EIF1B protein

EIF4EBP2 protein (His tag)

80R-1722 100 ug
EUR 305
Description: Purified recombinant Human EIF4EBP2 protein

HNRNPC protein (His tag)

80R-1723 10 ug
EUR 305
Description: Purified recombinant Human HNRNPC protein

PFDN6 protein (His tag)

80R-1724 50 ug
EUR 397
Description: Purified recombinant Human PFDN6 protein

S100A6 protein (His tag)

80R-1725 100 ug
EUR 305
Description: Purified recombinant Human S100A6 protein

S100A11 protein (His tag)

80R-1726 100 ug
EUR 305
Description: Purified recombinant Human S100A11 protein

S100A14 protein (His tag)

80R-1727 100 ug
EUR 305
Description: Purified recombinant Human S100A14 protein

TREX2 protein (His tag)

80R-1728 100 ug
EUR 305
Description: Purified recombinant Human TREX2 protein

HSPA13 protein (His tag)

80R-1729 100 ug
EUR 305
Description: Purified recombinant Human HSPA13 protein

EIF3K protein (His tag)

80R-1730 50 ug
EUR 305
Description: Purified recombinant Human EIF3K protein

NECAP2 protein (His tag)

80R-1731 100 ug
EUR 305
Description: Purified recombinant Human NECAP2 protein

RDBP protein (His tag)

80R-1732 100 ug
EUR 305
Description: Purified recombinant Human RDBP protein

RGS2 protein (His tag)

80R-1733 10 ug
EUR 305
Description: Purified recombinant Human RGS2 protein

MTHFS protein (His tag)

80R-1734 100 ug
EUR 305
Description: Purified recombinant Human MTHFS protein

ZCCHC17 protein (His tag)

80R-1735 50 ug
EUR 397
Description: Purified recombinant Human ZCCHC17 protein

PDCD6 protein (His tag)

80R-1736 50 ug
EUR 397
Description: Purified recombinant Human PDCD6 protein

CAPSL protein (His tag)

80R-1737 100 ug
EUR 397
Description: Purified recombinant Human CAPSL protein

ALDOC protein (His tag)

80R-1738 100 ug
EUR 305
Description: Purified recombinant Human ALDOC protein

ALKBH3 protein (His tag)

80R-1739 100 ug
EUR 305
Description: Purified recombinant Human ALKBH3 protein

CMPK1 protein (His tag)

80R-1740 100 ug
EUR 397
Description: Purified recombinant Human CMPK1 protein

CSTA protein (His tag)

80R-1741 100 ug
EUR 305
Description: Purified recombinant Human CSTA protein

DECR1 protein (His tag)

80R-1742 50 ug
EUR 457
Description: Purified recombinant Human DECR1 protein

DNAJB11 protein (His tag)

80R-1743 10 ug
EUR 349
Description: Purified recombinant Human DNAJB11 protein

LGALS7 protein (His tag)

80R-1744 100 ug
EUR 305
Description: Purified recombinant Human LGALS7 protein

MORF4L2 protein (His tag)

80R-1745 100 ug
EUR 305
Description: Purified recombinant Human MORF4L2 protein

PKIB protein (His tag)

80R-1746 100 ug
EUR 305
Description: Purified recombinant Human PKIB protein

PPP3R2 protein (His tag)

80R-1747 50 ug
EUR 305
Description: Purified recombinant Human PPP3R2 protein

RBM8A protein (His tag)

80R-1748 50 ug
EUR 397
Description: Purified recombinant Human RBM8A protein

S100A7 protein (His tag)

80R-1749 100 ug
EUR 305
Description: Purified recombinant Human S100A7 protein

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